Chemical structure of chlorogenic acid. It is a potent neuroprotectant and also possesses antiviral, antifungal, antioxidant and antitumor properties. Nutr. (, Multidisciplinary Digital Publishing Institute (MDPI). reported 69 CGAs, including 3,4,5-tricaffeoylquinic acid (3,4,5-triCQA), in green robusta coffee beans using tandem LC–MS.28 3,4,5-TriCQA has higher physiological activities such as anti-HIV and antioxidant activities than CQAs and diCQAs.18,30, The content of CGAs in green coffee beans varys with genes, species, climate, nutrient state of soil, processing process such as decaffeination, and degree of ripeness.31–37 Coffea arabica (arabica coffee) and Coffea canephora (robusta coffee) account for approximately 75% and 24%, respectively, of global coffee production. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, The effects of chlorogenic acid (CGA) on the regulation of glucose consumption and the prediction of its target proteins. Chlorogenic acid was isolated from green coffee beans. Copyright © 2020 Elsevier B.V. or its licensors or contributors. Dezocine regulates the malignant potential and aerobic glycolysis of liver cancer targeting Akt1/GSK-3β pathway. Please enable it to take advantage of the complete set of features! Chlorogenic acids are one of the most abundant polyphenols, and green coffee beans, along with certain fruits and vegetables, are among its richest dietary sources. The flavonoid baicalin improves glucose metabolism by targeting the PH domain of AKT and activating AKT/GSK3β phosphorylation. -, Gokcen B.B., Sanlier N. Coffee consumption and disease correlations. Here, CGA has the potential to alter the balance of gut microbiota.  |  Zhong ZW, Zhou WC, Sun XF, Wu QC, Chen WK, Miao CH. Development and effect of storage on the stability of enriched flavonoid fraction of Protective effects of Eucommia ulmoides Oliv. A competitive combination test and hampering of AKT membrane translocation showed that CGA might bind to the pleckstrin homology (PH) domain of AKT. CGA compounds and trans-hydroxycinnamic acids have been identified in freshly secreted human digestive fluid of 87 subjects, in free and conjugated forms, after 12-h fasting.21,29 Concentrations were in the order of magnitude of those observed in plasma after coffee consumption, with higher concentrations in conjugated forms.21,29 This finding indicates that digestive fluids are an excretion route for CGA and suggests the occurrence of CGA recycling in the human body by enterohepatic recirculation, since it is known that intestinal bacteria are able to hydrolyze sulfated and glucuronated phenolic compounds in the gastrointestinal tract, allowing for reabsorption.37,46 This is probably one of the reasons why in a few studies CGA and metabolites have been observed in baseline urine after 2-day low-phenolic diet followed by 24 h water and electrolytes intake only44 (unpublished data). Chlorogenic acid from coffee beans: Evaluating the evidence for a blood pressure-regulating health claim. In this chapter, we describe the contents of chlorogenic acids (CGAs) of various species of green and roasted coffee beans. The specific binding did not lead to the membrane translocation to phosphatidylinositol (3,4,5)-trisphosphate (PIP₃), but directly activated the phosphorylation of AKT on Ser-473, induced the phosphorylation of the downstream molecules, glycogen synthase kinase 3β (GSK3β) and forkhead box O1 (FOXO1), and improved glucose metabolism.