Calculation of drug-like molecules solubility using predictive activity coefficient models. Melting Point: 159°C (318°F). • Salicylic acid finds a lot of applications, particularly in the pharmaceutical industry. For ordering the dangerous good or other information please contact our customer service center. [16] It fluoresces in the blue at 420 nm. Determination of the activity of a molecular solute in saturated solution. A melting point tube is filled with the substance to be assayed. Salicylic acid is biosynthesized from the amino acid phenylalanine. Salicylic acid, European Pharmacopoeia (EP) Reference Standard, S-019 Salicylic acid, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant ® , We are represented by agencies throughout the world. Abraham model correlations for estimating solute transfer of neutral molecules into anhydrous acetic acid from water and from the gas phase. Discussion and Improvement of the Refined COSMO-SAC Parameters for Solubility Predictions: Part 2. m-Hydroxybenzoic Acid: Quantifying Thermodynamic Stability and Influence of Solvent on the Nucleation of a Polymorphic System. JavaScript seems to be disabled in your browser. Assessing the Salting-Out Behavior of Nitrobenzene, 2-Nitrotoluene, and 3-Nitrotoluene from Solubility Values in Pure Water and Seawater at Temperatures between (277 and 314) K. António J. Queimada, Fátima L. Mota, Simão P. Pinho and Eugénia A. Macedo . It is lipophilic in nature. Salicylic Acid-grafted Chitosan Oligosaccharide Nanoparticle for Paclitaxel Delivery. Dipali Ahuja, Michael Svärd, Åke C. Rasmuson. However, too much salicylic acid should not be used on the skin as it may cause hyperpigmentation in people with dark skin tones. Martins, Liliana P. Silva, Tatiana B. Schreiner, Luciano Fernandes, Olga Ferreira, Simão P. Pinho. Salicylic Acid is a small aromatic acid whose chemical name is monohydroxybenzoic acid. Vânia André, Inês Martins, Sílvia Quaresma, Marta Martins, M. Teresa Duarte. David Méndez Sevillano, Luuk A.M. van der Wielen, Nasim Hooshyar, Marcel Ottens. Zilin Meng, Fengzhu Lv, Yihe Zhang, Qian Zhang, Zhilei Zhang, Shutao Ai. It is lipophilic in nature. Masoud Salavati-Niasari, Zeynab Behfard, Mahnaz Maddahfar. The salt and ester derivatives of this compound are also widely used in organic chemistry and are known as salicylates. Show. Xiao-Hong Wei, Yang-Ping Niu, Yang-Yan Xu, Yong-Zhong Du, Fu-Qiang Hu, Hong Yuan. However, it is advised by the health agencies do not use salicylic acid medications on genital warts or warts containing hair growths. Find more information about Crossref citation counts. Determination and Correlation of Solubilities of Benzoic Acid, Salicylic Acid, Resorcinol and Hydroquinone in Water and in 1-Octanol at Temperatures from 297.25 K to 334.45 K. Shubhangi Kakkar, K. Renuka Devi, Michael Svärd, Åke Rasmuson. Berkant Kayan, Yu Yang, Edward J. Lindquist and A. Murat Gizir . [19], If high concentrations of salicylic ointment are applied to a large percentage of body surface, high levels of salicylic acid can enter the blood, requiring hemodialysis to avoid further complications. It does not let the skin pores clog and the ones that are already clogged can be opened by the application of salicylic acid over that particular area. It was first derived from the bark of Willow Tree. Pro, CBSE Previous Year Question Paper for Class 10, CBSE Previous Year Question Paper for Class 12, • Salicylic Acid exist as clear white or colourless and odourless needle-shaped crystals at room temperature, • The boiling point and melting point of Salicylic Acid are 211 °C and 315 °C, respectively, • Salicylic Acid contains two hydrogen bond donors and three hydrogen bond acceptors in its molecule, • The flash point of Salicylic Acid is 157 °C, • Due to its lipophilic nature, its solubility in water is very poor [1.8 g/L (at 25 °C)], • Salicylic Acid is soluble in organic solvents such as carbon tetrachloride, benzene, propanol, ethanol and acetone, • The density of Salicylic Acid is 1.44 at 20 °C, • It is a tendency to undergo discolouration when exposed to direct sunlight due to its photochemical degradation, • Upon degradation, it emits irritating fumes and acrid smelling smoke, • Its heat of combustion is3.026mj/moleat 25 °C, • The pH of a saturated solution of Salicylic Acid is2.4, • Its pKa (dissociation constant) is 2.97. Modified Na-Montmorillonite With Quaternary Ammonium Salts: Application for Removal of Salicylic Acid From Aqueous Solutions. The melting point is determined by slow heating in the water bath. per page . Salicylic acid occurs in plants as free salicylic acid and its carboxylated esters and phenolic glycosides. Hirihattaya Phetmung, Kanlayanee Musikapong, Teerapol Srichana. States of matter, Geometrical optics on the precision metal rail, Radioactivity with the radium preparation, Heaters, stirrers, pumps, laboratory accessories, Synthesis and purification of organic compounds, Products made from renewable raw materials, Experiments with the Electrochemistry Workplace, The washing and cleaning effects of soaps, Disadvantages and limits to the use of soaps, Physical-Chemical Effects (abiotic factors), Fundamentals of car electrics/electronics, Networking automotive and diagnosis systems, Fundamentals of electronics and electrics, COM3LAB Multimedia: Fundamentals of Electrical Engineering, Electrical power transmission and distribution, Determination of the melting point of salicylic acid. [17], 17% to 27% salicylic acid used in the form of a paint, and 20% to 50% in plaster form, which are sold for wart and corn removal should not be applied to the face and should not be used for acne treatment. Engineering cocrystal thermodynamic stability and eutectic points by micellar solubilization and ionization. All carbon atoms present in the benzene ring of Salicylic Acid are sp, Preparation of Standard Solution of Oxalic Acid, Classification of Elements and Periodicity in Properties, NCERT Solutions for Class 11 Chemistry Chapter 3, NCERT Solutions for Class 11 Chemistry Chapter 4, NCERT Solutions for Class 11 chemistry chapter 2 – Structure of Atom, NCERT Solutions for Class 11 Chemistry Chapter 2 Structure of Atom In Hindi, NCERT Solutions for Class 11 Chemistry Chapter 3 Classification of Elements and Periodicity in Properties In Hindi, NCERT Solutions for Class 7 Maths Chapter 6 The Triangle and its Properties, NCERT Solutions for Class 11 Chemistry Chapter 4 Chemical Bonding and Molecular Structure In Hindi, Cell Structure and Functions NCERT Solutions - Class 8 Science, NCERT Solutions for Class 11 Physics Chapter 9, NCERT Solutions for Class 11 Physics Chapter 11, Class 11 Chemistry Revision Notes for Chapter 3 - Classification of Elements and Periodicity in Properties, Class 11 Chemistry Revision Notes for Chapter 4 - Chemical Bonding and Molecular Structure, Class 11 Chemistry Notes for Chapter 2 - Structure of Atom, CBSE Class 7 Maths Chapter 6 - Triangle and Its Properties Formulas, CBSE Class 11 Physics Thermal Properties of Matter Formulas, CBSE Class 11 Physics Mechanical Properties of Fluids Formulas, CBSE Class 11 Physics Mechanical Properties of Solids Formulas, Class 11 Physics Revision Notes for Chapter 9 - Mechanical Properties of Solids, Class 11 Physics Revision Notes for Chapter 11 - Thermal Properties of Matter, Class 11 Physics Revision Notes for Chapter 10 - Mechanical Properties of Fluids, Vedantu It is also known as 2-hydroxybenzoic acid. An evaluation of thermodynamic models for the prediction of drug and drug-like molecule solubility in organic solvents. Jianfeng Hao, Wenge Yang, Hongjie Li, Shimin Fan, Wangdan Zhao, and Yonghong Hu . The melting point is, along with the boiling point, a characteristic property of every substance. Solubility and Thermodynamic Properties of A Hexanediamine Derivative in Pure Organic Solvents and Nonaqueous Solvent Mixtures. Salicylate may competitively inhibit prostaglandin formation. The salts and esters of salicylic acid are known as salicylates. Pro, Vedantu Lanolin-based organogel of salicylic acid: evidences of better dermatokinetic profile in imiquimod-induced keratolytic therapy in BALB/c mice model. The signal can also move to nearby plants by salicylic acid being converted to the volatile ester methyl salicylate. Another analgesic formed from salicylic acid is methyl salicylate (also commonly known as the oil of wintergreen), an esterified product of salicylic acid. Si Li, Lingyu Wang, Minghe Zhu, Dandan Han, Ya Liu, Mingyang Chen, Jie Hou, and Junbo Gong . Please reconnect. [20], Salicylic acid has the formula C6H4(OH)COOH, where the OH group is ortho to the carboxyl group. Phase Equilibria of the System Drug + Water. Baptiste Bouillot, Sébastien Teychené, Béatrice Biscans. Solubility of Benzoin in Six Monosolvents and in Some Binary Solvent Mixtures at Various Temperatures. Solubility of pharmaceuticals in water and alcohols. Size and Shape Control of Micron-Sized Salicylic Acid Crystals during Antisolvent Crystallization. Salicylic acid degrades to phenol and carbon dioxide at 200 - 230°C:[23], Hippocrates, Galen, Pliny the Elder and others knew that willow bark could ease pain and reduce fevers. A correlation was observed between the solubility and the van't Hoff enthalpy of solution. Journal of Thermal Analysis and Calorimetry. Andreia de P. M. da Silva and João F. Cajaiba da Silva . It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. Solubilities of Biologically Active Phenolic Compounds: Measurements and Modeling.