This can cause dissociation of cellular membrane lipid bilayers, which compromises cellular permeability controls and induces leakage of cellular contents. Benzalkonium chloride is a mainstay of phase-transfer catalysis, an important technology in the synthesis of organic compounds, including drugs. While early studies confirmed the corrosive and irritant properties of benzalkonium chloride, investigations into the adverse effects of, and disease states linked to, benzalkonium chloride have only surfaced during the past 30 years. Benzalkonium chloride solutions are fast-acting biocidal agents with a moderately long duration of action. EC number: 202-710-8 | CAS number: 98-88-4. D. Chlorophenyl ketone. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. This website uses cookies to ensure you get the best experience on our websites. [citation needed] The use of appropriate excipients can also greatly enhance the spectrum, performance and detergency, and prevent deactivation under use conditions. Other names … Close Find out more on how we use cookies. The trimethyl amine group in dimethylbenzylamine can be cleaved to form a benzyl that can be further oxidized to benzoic acid. [25], Benzalkonium chloride has been in common use as a pharmaceutical preservative and antimicrobial since the 1940s. Close Find out more on how we use cookies. Exit. C. Benzene carbonyl chloride. *Disclaimer: The IUPAC, INCHI, and SMILES data on this page has its source from CompTox. Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable … For more information about the substance, you may click one of the links below to take you to the relevant section: Below are the EPA applications/systems, statutes/regulations, or other sources that track or regulate this substance. B. Benzene chloro ketone. Biphenyl-4-carbonyl chloride. The FDA has stated that benzalkonium chloride is eligible as an alternative for use in the formulation of healthcare personnel hand rubs. [31], Poisoning by benzalkonium chloride is recognised in the literature. Aqueous solutions should be neutral to slightly alkaline. Benzylamine is an organic chemical compound with the condensed structural formula C 6 H 5 CH 2 NH 2 (sometimes abbreviated as PhCH 2 NH 2 or BnNH 2).It consists of a benzyl group, C 6 H 5 CH 2, … [12], Avoiding the use of benzalkonium chloride solutions while contact lenses are in place is discussed in the literature.[13][14]. IUPAC Standard InChIKey: KCXMKQUNVWSEMD-UHFFFAOYSA-N; CAS Registry Number: 100-44-7; Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file The 3d … EC number: 202-710-8 | CAS number: 98-88-4. This is done by abstracting the hydrogen from the alkyl chain by using a hydroxyl radical leading to a carbon centered radical. [36], The greatest biocidal activity is associated with the C12 dodecyl and C14 myristyl alkyl derivatives. This results in benzyl dimethyl amine as the first intermediate and dodecanal as the major product.[39]. Solutions are bacteriostatic or bactericidal according to their concentration. Tablets are inserted vaginally, or a gel is applied, resulting in local spermicidal contraception. While the majority of cases were caused by confusion about the contents of containers, one case cites incorrect pharmacy dilution of benzalkonium chloride as the cause of poisoning of two infants. This site is not fully supported in Internet Explorer 7 (and earlier versions). [citation needed], Newer formulations using benzalkonium blended with various quaternary ammonium derivatives can be used to extend the biocidal spectrum and enhance the efficacy of benzalkonium based disinfection products. [citation needed], Many mass-marketed inhaler and nasal spray formulations contain benzalkonium chloride as a preservative, despite substantial evidence that it can adversely affect ciliary motion, mucociliary clearance, nasal mucosal histology, human neutrophil function, and leukocyte response to local inflammation. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner. Benzyldimethylamine can then be converted into ammonia by performing demethylation twice, which removes both methyl groups, followed by debenzylation, removing the benzyl group using hydrogenation.